Preferred Label : IL-10-armed Anti-CD19 CAR-T Cells Meta10-19;
NCIt synonyms : IL-10-armed Anti-CD19 CAR T Cells Meta10-19; Metabolically Armed CD19 CAR-T Cells Meta10-19; IL-10-armed Anti-CD19 CAR T-cells Meta10-19;
NCIt definition : A preparation of T-lymphocytes that have been genetically modified to express a chimeric
antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19, and armed
with the anti-inflammatory cytokine interleukin-10 (IL-10), with potential immunostimulating
and antineoplastic activities. Upon administration, IL-10-armed anti-CD19 CAR-T cells
Meta10-19 recognize and bind to CD19-expressing tumor cells, thereby inducing selective
toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface
antigen overexpressed in B-cell lineage malignancies. IL-10 may stimulate the differentiation
and expansion of tumor specific cytotoxic CD8 T-cells.;
NCI Metathesaurus CUI : CL1907094;
Origin ID : C200265;
concept_is_in_subset
- has_target
