Preferred Label : Anti-CLDN6/CD3 Bispecific Antibody SAIL66;
NCIt synonyms : CLDN6 x CD3 Bispecific Antibody SAIL66; Anti-CLDN6/Anti-CD3 Bispecific Antibody SAIL66;
NCIt definition : A bispecific antibody targeting both the tumor-associated antigen (TAA) Claudin 6
(CLDN6; CLDN-6) and the T-cell surface antigen CD3, with potential immunostimulating
and antineoplastic activities. Upon intravenous administration, anti-CLDN6/CD3 bispecific
antibody SAIL66 targets and binds to both CLDN6 expressed on tumor cells and CD3 expressed
on T-cells. This activates and redirects cytotoxic T-lymphocytes (CTLs) to CLDN6-expressing
tumor cells, which leads to enhanced CTL-mediated killing of CLDN6-expressing tumor
cells. CLDN6, a tight-junction protein and embryonic antigen, is expressed on a variety
of tumor cells but is not expressed on normal, healthy adult cells.;
Molecule name : SAIL-66; SAIL 66;
NCI Metathesaurus CUI : CL1907043;
Origin ID : C200201;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
