NCIt definition : A monoclonal antibody against the inhibitory T-cell receptor T-cell immunoglobulin
and mucin domain-containing protein 3 (TIM-3; TIM3; hepatitis A virus cellular receptor
2; HAVCR2), with potential immune checkpoint inhibitory and antineoplastic activities.
Upon administration, anti-TIM-3 monoclonal antibody BC3402 targets and binds to TIM-3
expressed on certain T-cells, including tumor infiltrating lymphocytes (TILs). This
abrogates T-cell inhibition, activates antigen-specific T-lymphocytes and enhances
cytotoxic T-lymphocyte (CTL)-mediated tumor cell lysis, which results in a reduction
in tumor growth. TIM-3, a transmembrane protein and immune checkpoint receptor, is
associated with tumor-mediated immune suppression.;
Semantic type(s)