NCIt definition : A humanized monoclonal antibody directed against interleukin-11 (IL-11), with potential
anti-fibrotic and antineoplastic activities. Upon administration, anti-IL-11 monoclonal
antibody 9MW3811 targets and binds to IL-11. This prevents the binding of IL-11 to
interleukin-11 receptor subunit alpha (IL-11RA), and inhibits IL-11-mediated signaling
via the gp130/IL-11RA receptor complex. This may decrease fibrosis and inhibit tumor
cell proliferation. IL-11, a member of the IL-6 family of cytokines, is upregulated
in some fibro-inflammatory diseases and cancers.;
Semantic type(s)