Preferred Label : Anti-CD70 Antibody-drug Conjugate PRO1160;
NCIt synonyms : Anti-CD70 ADC PRO1160;
NCIt definition : An antibody-drug conjugate (ADC) consisting of a human monoclonal antibody directed
against the tumor-associated antigen (TAA) cluster of differentiation 70 (CD70), conjugated
via a cleavable, hydrophilic linker to the camptothecin analog exatecan, with potential
antineoplastic activity. Upon administration of anti-CD70 ADC PRO1160, the anti-CD70
antibody moiety targets and binds to CD70-expressing tumor cells. Upon binding, internalization
and linker cleavage, exatecan is released. Exatecan inhibits DNA topoisomerase I activity,
thereby inhibiting DNA replication and resulting in cell cycle arrest and tumor cell
apoptosis. This inhibits the proliferation of CD70-expressing tumor cells. CD70, the
ligand for the costimulatory receptor CD27 and a member of the tumor necrosis factor
(TNF) family, is found on the surfaces of various types of cancer cells.;
Molecule name : PRO-1160; PRO 1160;
NCI Metathesaurus CUI : CL1906970;
Origin ID : C200126;
UMLS CUI : C5854477;
Semantic type(s)
- concept_is_in_subset
- has_target
