Preferred Label : Anti-PD-1 Monoclonal Antibody OSE-279;
NCIt synonyms : Anti-PD1 Monoclonal Antibody OSE-279;
NCIt definition : A human immunoglobulin G4 (IgG4) monoclonal antibody directed against the negative
immunoregulatory human cell receptor programmed cell death protein 1 (PD-1; PDCD1;
CD279), with potential immune checkpoint inhibitory and antineoplastic activities.
Upon administration, anti-PD-1 monoclonal antibody OSE-279 targets, binds to and inhibits
PD-1 and its downstream signaling pathways. This may restore immune function through
the activation of T-cells and T-cell-mediated immune responses against tumor cells.
PD-1, a transmembrane protein in the immunoglobulin superfamily (IgSF) expressed on
T-cells, functions as an immune checkpoint that negatively regulates T-cell activation
and effector function when activated by its ligands programmed cell death-1 ligand
1 (PD-L1; cluster of differentiation 274; CD274) or 2 (PD-L2; CD273); it plays an
important role in tumor evasion from host immunity.;
Molecule name : OSE 279; OSE-279;
NCI Metathesaurus CUI : CL1906964;
Origin ID : C200120;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
