NCIt definition : A bispecific antibody directed against both claudin-4 (CLDN4) and CD137 (4-1BB; tumor
necrosis factor receptor superfamily member 9; TNFRSF9), with potential immunostimulating
and antineoplastic activities. Upon administration, anti-CLDN4/anti-CD137 bispecific
antibody ASP1002 simultaneously targets and binds to CLDN4 expressed on tumor cells
and 4-1BB expressed on a variety of leukocyte subsets including activated T-lymphocytes.
The simultaneous binding to CLDN4 and CD137 allows for conditional stimulation of
CD137 signaling within the tumor microenvironment (TME) only upon binding to CLDN4
on tumor cells. CD137 activation results in T-cell stimulation and enhances T-lymphocyte-mediated
anti-tumor immune response against CLDN4-expressing tumor cells. CLDN4, a claudin
protein family member that regulates tight junction formation, is overexpressed on
a variety of tumor cells. 4-1BB, a surface glycoprotein of the tumor necrosis factor
receptor superfamily, is an inducible costimulatory receptor that plays a key role
in T-cell proliferation, survival and cytolytic activity.;
Semantic type(s)