Preferred Label : Fc Fusion IL-7 Mimetic MDK-703;
NCIt synonyms : IL-7 PEPTIKINE-Fc-domain Fusion Protein MDK-703; Fc-Peptide-Based IL-7 Mimetic MDK-703; IL-7 Mimetic MDK-703; IL-7R Agonist MDK-703;
NCIt definition : A fusion protein composed of MDK-1472, a structurally unrelated engineered mimetic
peptide of endogenous human cytokine interleukin-7 (hIL-7), fused to an immunoglobulin
G2 (IgG2) Fc-domain, with hematopoietic and immunopotentiating activities. Upon administration,
Fc fusion IL-7 mimetic MDK-703 mimics endogenous cytokine IL-7 and binds to the IL-7
receptor (IL7R) on immune cells. The binding of IL-7 to IL7R activates IL7/IL7R-mediated
signaling, which leads to the expansion of various subsets of T-lymphocytes, including
memory T-cells, especially CD8 and CD4 stem cell memory T-cells (Tscm), central memory
T-cells (Tcm) and effector memory T-cells (Tem). This may improve immune recovery
and activation and may enhance T-cell-mediated anti-tumor immune responses. Fusion
to the Fc domain enhances the half-life of the IL-7 mimetic. As MDK-703 is unrelated
in sequence to the natural cytokine, it is unlikely to generate anti-drug antibodies
(ADAs) that neutralize the endogenous IL-7 cytokine. IL-7 is a cytokine critical for
the development, maintenance and survival of T-cell subpopulations.;
Molecule name : MDK-703; MDK 703;
NCI Metathesaurus CUI : CL1906531;
Origin ID : C199626;
UMLS CUI : C5854442;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
