Preferred Label : PARG Inhibitor IDE161;
NCIt definition : An orally bioavailable, small molecule inhibitor of poly (ADP-Ribose) (PAR) glycohydrolase
(PARG), with potential antineoplastic activity. Upon oral administration, PARG Inhibitor
IDE161 targets, binds to and inhibits the activity of PARG, thereby inhibiting the
hydrolysis of PAR chains by PARG. This attenuates DNA repair and induces mitotic arrest,
ultimately leading to apoptosis. PARG, the only enzyme responsible for hydrolyzing
PAR chains produced by poly (ADP-ribose) polymerase (PARP) 1, plays a key role in
the resolution of PARP 1/2-dependent DNA damage repair.;
Molecule name : IDE-161; IDE 161;
NCI Metathesaurus CUI : CL1906522;
Origin ID : C199624;
UMLS CUI : C5854441;
Semantic type(s)
- concept_is_in_subset
- has_target
