High Grade B-Cell Lymphoma with MYC and BCL6 Rearrangements

Preferred Label : High Grade B-Cell Lymphoma with MYC and BCL6 Rearrangements;

NCIt synonyms : HGBCL-DH-BCL6; High-Grade B-Cell Lymphoma with MYC and BCL6 Rearrangements;

NCIt definition : High-grade B-cell lymphoma characterized by the abnormal rearrangement of MYC and BCL6 genes.;

Neoplastic status : Malignant;

Concept status : Provisional_Concept;

NCI Metathesaurus CUI : CL1906524;

Details

Origin ID

C199618;

UMLS CUI

C5854274;

Disease excludes abnormal cell
- Lymphocyte Predominant Cell [NCIt concept]
- Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell [NCIt concept]
- Reed-Sternberg Cell [NCIt concept]
Disease excludes normal cell origin
- Myeloid Cell [NCIt concept]
- Plasma Cell [NCIt concept]
- Precursor B-Lymphoblast [NCIt concept]
Disease may have findings
- Aggressive Clinical Course [NCIt concept]
Has associated anatomic sites
- Hematopoietic and Lymphatic System [NCIt concept]
Has cytogenetic abnormalities
- BCL6 Gene Rearrangement [NCIt concept]
- MYC Gene Rearrangement [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
disease_has_abnormal_cell
- Abnormal Lymphocyte [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic B-Lymphocyte [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Large B-Lymphocyte [NCIt concept]
- Neoplastic Lymphocyte [NCIt concept]
disease_has_finding
- Diffuse Pattern [NCIt concept]
- Double Hit Lymphoproliferative Lesion [NCIt concept]
- MYC Gene Rearrangement and BCL6 Gene Rearrangement Positive [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
disease_has_grade
- High Grade [NCIt concept]
disease_has_molecular_abnormality
- Clonal Immunoglobulin Gene Rearrangement [NCIt concept]
- Clonal Immunoglobulin Kappa Light Chain Gene Rearrangement [NCIt concept]
disease_has_normal_cell_origin
- B-Lymphocyte [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Lymphocyte [NCIt concept]
- Mature B-Lymphocyte [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic and Lymphoid Tissue [NCIt concept]
- Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Hematopoietic and Lymphatic System [NCIt concept]
- Lymphatic System [NCIt concept]
disease_mapped_to_gene
- BCL6 Gene [NCIt concept]
- MYC Gene [NCIt concept]
disease_may_have_molecular_abnormality
- Clonal Immunoglobulin Heavy Chain Gene Rearrangement [NCIt concept]
- Clonal Immunoglobulin Lambda Light Chain Gene Rearrangement [NCIt concept]
pathogenesis_of_disease_involves_gene
- BCL6 Gene [NCIt concept]
- BCL6 wt Allele [NCIt concept]

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