Preferred Label : SARS-CoV-2 Replicase Polyprotein 1ab;
NCIt synonyms : ORF1ab; pp1ab; Replicase Polyprotein 1ab; Severe Acute Respiratory Syndrome Coronavirus 2 Replicase Polyprotein 1ab; SARS Coronavirus 2 Replicase Polyprotein 1ab; SARS2 Replicase Polyprotein 1ab; ORF1ab Polyprotein; SARS-2 Replicase Polyprotein 1ab;
NCIt definition : SARS-CoV-2 replicase polyprotein 1ab (7096 aa, 794 kDa) is encoded by the SARS-CoV-2
ORF1ab gene. This protein is involved in self-proteolysis that yields 15 non-structural
viral proteins that replicate and transcribe the viral genome.;
NCIt note : SARS-CoV-2 replicase polyprotein 1ab is self-cleaved to release the following 15 non-structural
viral proteins: host translation inhibitor nsp1 (leader protein, non-structural protein
1, nsp1); non-structural protein 2 (nsp2, p65 homolog); papain-like protease nsp3
(non-structural protein 3, nsp3, PL2-PRO, papain-like proteinase, PL-PRO, EC 3.4.19.12,
EC 3.4.22.-); non-structural protein 4 (nsp4); 3C-like proteinase nsp5 (3CL-PRO, 3CLp,
main protease Mpro, non-structural protein 5, nsp5, SARS coronavirus main proteinase,
EC 3.4.22.692); non-structural protein 6 (nsp6); non-structural protein 7 (nsp7);
non-structural protein 8 (nsp8); RNA-capping enzyme subunit nsp9 (non-structural protein
9, nsp9, EC 2.7.7.50); non-structural protein 10 (nsp10, growth factor-like peptide,
GFL); RNA-directed RNA polymerase nsp12 (Pol, RdRp, non-structural protein 12, nsp12,
EC 2.7.7.48); helicase nsp13 (Hel, non-structural protein 13, nsp13, EC 3.6.4.12,
EC 3.6.4.13); guanine-N7 methyltransferase nsp14 (non-structural protein 14, nsp14,
proofreading exoribonuclease nsp14, ExoN, EC 2.1.1.56, EC 3.1.13.-); uridylate-specific
endoribonuclease nsp15 (NendoU, non-structural protein 15, nsp15, EC 4.6.1.-); and
2'-O-methyltransferase nsp16 (non-structural protein 16, nsp16, EC 2.1.1.57). (UniProt);
NCI Metathesaurus CUI : CL1906804;
Origin ID : C199435;
UMLS CUI : C5848557;
Semantic type(s)
- concept_is_in_subset
- gene_encodes_gene_product
- gene_product_has_organism_source
