Preferred Label : Anti-B7-H4/Anti-CD3 Bispecific Antibody GEN1047;
NCIt synonyms : DuoBody-CD3xB7H4 GEN1047;
NCIt definition : A bispecific monoclonal antibody against both B7-H4 (V-set domain-containing T-cell
activation inhibitor 1; VTCN1; B7x; B7S1) and T-cell surface antigen CD3, with potential
immunostimulating and antineoplastic activities. Upon administration, anti-B7-H4/anti-CD3
bispecific antibody GEN1047 targets and binds to both B7-H4 on the surface of tumor
cells and CD3 on T-cells. This results in the cross-linking of tumor cells and T-cells,
and induces a cytotoxic T-lymphocyte (CTL) response against B7-H4-expressing tumor
cells. B7-H4, a member of the B7 family of immune modulators, is upregulated in a
variety of tumor cell types and negatively regulates T-cell immune responses.;
Molecule name : GEN 1047; GEN-1047;
NCI Metathesaurus CUI : CL1906807;
Origin ID : C199432;
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target