NCIt definition : A bispecific monoclonal antibody against both B7-H4 (V-set domain-containing T-cell
activation inhibitor 1; VTCN1; B7x; B7S1) and T-cell surface antigen CD3, with potential
immunostimulating and antineoplastic activities. Upon administration, anti-B7-H4/anti-CD3
bispecific antibody GEN1047 targets and binds to both B7-H4 on the surface of tumor
cells and CD3 on T-cells. This results in the cross-linking of tumor cells and T-cells,
and induces a cytotoxic T-lymphocyte (CTL) response against B7-H4-expressing tumor
cells. B7-H4, a member of the B7 family of immune modulators, is upregulated in a
variety of tumor cell types and negatively regulates T-cell immune responses.;
Semantic type(s)