NCIt definition : A humanized monoclonal antibody targeting the immune checkpoint molecule sialic acid-binding
immunoglobulin (Ig)-like lectin 15 (Siglec-15; SIGLEC15; S15; CD33L3), with potential
immune checkpoint inhibitory, antineoplastic and immunomodulatory activities. Upon
administration, aldastotug targets and binds to S15 on the surface of tumor-associated
macrophages (TAMs) and certain tumor cells. Binding to S15 may disrupt TAM-mediated
activities such as promotion of tumor initiation and metastasis of tumor cells and
inhibition of CD8-positive and CD4-positive T-cell responses. This leads to activation
of the immune system and an inhibition of tumor cell growth. S15, a highly conserved
type 1 cell surface protein, normally involved in osteoclast differentiation and bone
remodeling, is overexpressed on and may play a key role in the survival and differentiation
of TAMs and various tumor cells.;
UNII : P63Y458LB9;
CAS number : 2865844-59-1;
Molecule name : BSI-060T; PYX-106; BSI 060T; PYX 106;
Semantic type(s)