Preferred Label : Anti-Siglec-15 Monoclonal Antibody PYX-106;
NCIt synonyms : Anti-S15 Monoclonal Antibody PYX-106; Anti-Siglec-15 Monoclonal Antibody BSI-060T;
NCIt definition : A humanized monoclonal antibody targeting the immune checkpoint molecule sialic acid-binding
immunoglobulin (Ig)-like lectin 15 (Siglec-15; SIGLEC15; S15; CD33L3), with potential
immune checkpoint inhibitory, antineoplastic and immunomodulatory activities. Upon
administration, anti-S15 monoclonal antibody PYX-106 targets and binds to S15 on the
surface of tumor-associated macrophages (TAMs) and certain tumor cells. Binding to
S15 may disrupt TAM-mediated activities such as promotion of tumor initiation and
metastasis of tumor cells and inhibition of CD8-positive and CD4-positive T-cell responses.
This leads to activation of the immune system and an inhibition of tumor cell growth.
S15, a highly conserved type 1 cell surface protein, normally involved in osteoclast
differentiation and bone remodeling, is overexpressed on and may play a key role in
the survival and differentiation of TAMs and various tumor cells.;
Molecule name : BSI-060T; PYX-106; BSI 060T; PYX 106;
NCI Metathesaurus CUI : CL1906750;
Origin ID : C199372;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
