Preferred Label : Anti-TROP-2/Topoisomerase Inhibitor ADC MHB036C;
NCIt synonyms : ADC MHB036C; Antibody-drug Conjugate MHB036C; Anti-TROP-2/TopoI ADC MHB036C;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody targeting the tumor-associated
antigen (TAA) trophoblast cell surface protein 2 (trophoblast antigen 2; calcium signal
transducer 2; TROP2; TROP-2; TACSTD2; GA733-1; M1S1) conjugated to an as of yet undisclosed
topoisomerase inhibitor (TopoI), with potential antineoplastic activity. Upon administration
of the anti-TROP-2/TopoI ADC MHB036C, the anti-TROP-2 antibody targets and binds to
TROP-2 expressed on tumor cells. Upon binding, internalization and cleavage, TopoI
is released, and inhibits DNA topoisomerase activity, thereby inhibiting DNA replication
and resulting in cell cycle arrest and tumor cell apoptosis. This inhibits the proliferation
of TROP-2-expressing tumor cells. TROP-2 is a transmembrane protein overexpressed
in various tumors. Its expression is associated with enhanced tumor aggressiveness,
metastasis, drug resistance and increased tumor cell survival.;
Molecule name : ZG 157; ZG-157; MHB-036C; MHB 036C;
NCI Metathesaurus CUI : CL1906224;
Origin ID : C199292;
concept_is_in_subset
- has_target
