Preferred Label : Lead Pb 203 VMT-a-NET;
NCIt synonyms : [203Pb]VMT-alpha-NET; 203Pb-PSC-PEG2-TOC; [203Pb]PSC-PEG2-TOC; 203Pb-VMT-a-NET; Lead Pb 203 PSC-PEG2-TOC; [203Pb]Pb-PSC-PEG-T;
NCIt related terms : [203Pb]VMT-a-NET;
NCIt definition : A radioconjugate consisting of the human somatostatin receptor subtype 2 (SSTR2)-targeting
peptide and Tyr3-octreotide (TOC) analog VMT-a-NET, in which the N-terminus of TOC
is conjugated, via polyethylene glycol (PEG) linkers (PEG2), to the cyclen-based lead-specific
chelator PSC and labeled with the gamma-emitting radioisotope lead Pb 203, with potential
imaging activity of neuroendocrine tumors (NETs) using single photon emission computed
tomography (SPECT)/computed tomography (CT). Upon administration of lead Pb 203 VMT-a-NET,
the peptide moiety specifically targets and binds to SSTR2, which is present on the
cell membranes of many types of NETs. This allows for visualization of SSTR2-positive
cells upon SPECT/CT imaging. SSTR2 is overexpressed on NETs and their metastases while
most other normal tissues express low levels of SSTR2.;
NCI Metathesaurus CUI : CL1906217;
Origin ID : C199287;
UMLS CUI : C5855518;
Semantic type(s)
concept_is_in_subset
has_target