NCIt definition : An agonist of the stimulator of interferon genes protein (STING; transmembrane protein
173; TMEM173), with potential immunoactivating and antineoplastic activities. Upon
intravenous administration, dazostinag targets and binds to STING and activates the
STING pathway in immune cells in the tumor microenvironment (TME). This leads to the
production of pro-inflammatory cytokines, including interferons (IFNs), enhances the
cross-presentation of tumor-associated antigens (TAAs) by dendritic cells (DCs), and
induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells.
STING, a transmembrane protein that activates immune cells in the TME, plays a key
role in the activation of the innate immune system.;
Semantic type(s)