NCIt definition : The disodium salt form of dazostinag, an agonist of the stimulator of interferon genes
protein (STING; transmembrane protein 173; TMEM173), with potential immunoactivating
and antineoplastic activities. Upon intravenous administration, dazostinag targets
and binds to STING and activates the STING pathway in immune cells in the tumor microenvironment
(TME). This leads to the production of pro-inflammatory cytokines, including interferons
(IFNs), enhances the cross-presentation of tumor-associated antigens (TAAs) by dendritic
cells (DCs), and induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against
cancer cells. STING, a transmembrane protein that activates immune cells in the TME,
plays a key role in the activation of the innate immune system.;
Semantic type(s)