" /> Puxitatug Samrotecan - CISMeF





Preferred Label : Puxitatug Samrotecan;

NCIt synonyms : Anti-B7-H4/Topoisomerase I Inhibitor ADC AZD8205; Antibody-drug Conjugate AZD8205; B7-H4 TOP1i ADC AZD8205; Anti-B7-H4/TOP1i ADC AZD8205; ADC AZD8205;

NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against B7-H4 (V-set domain-containing T-cell activation inhibitor 1; VTCN1; B7x; B7S1) linked to a topoisomerase-1 inhibitor (TOP1i; TOP-Ii), with potential antineoplastic activity. Upon administration, the anti-B7-H4 monoclonal antibody moiety of puxitatug samrotecan targets and binds to B7-H4 expressed on tumor cells. Upon binding and internalization, the TOP1i moiety is released, binds to TOP1 and stabilizes cleaved DNA-TOP1 complexes. This prevents DNA re-ligation, induces irreversible DNA strand breaks, prevents DNA repair, and leads to cycle arrest and apoptosis specifically in tumor cells expressing B7-H4. B7-H4, a member of the B7 family of immune modulators, is upregulated in a variety of tumor cell types and tumor-associated macrophages. It negatively regulates T-cell immune responses.;

UNII : 396QL65J3Q;

CAS number : 2760250-80-2;

Molecule name : AZD 8205; AZD-8205;

NCI Metathesaurus CUI : CL1906046;

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02/08/2025


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