Preferred Label : Pocenbrodib;
NCIt synonyms : p300/CBP Bromodomain Inhibitor FT-7051; CBP/p300 Bromodomain Inhibitor FT-7051;
NCIt definition : An orally bioavailable inhibitor of the bromodomain of the histone acetyltransferase
(HAT) paralogs, CREB binding protein (CBP) and p300 (E1A-associated protein p300;
p300 HAT), with potential antineoplastic activity. Upon oral administration, pocenbrodib
targets and binds to the bromodomain of CBP and p300. This disrupts the acetylation
of histones and other proteins and prevents the co-activation of the androgen receptor
(AR) including AR-v7. This may inhibit tumor cell proliferation in AR-positive tumor
cells. The HAT paralogs CBP and p300 are key transcriptional co-activators that are
essential for a multitude of cellular processes and are implicated in the progression
and therapeutic resistance of certain cancers.;
UNII : EI2N46W53Z;
CAS number : 2304372-79-8;
Molecule name : FT 7051; FT-7051;
NCI Metathesaurus CUI : CL1906034;
Origin ID : C199092;
UMLS CUI : C5855361;
Semantic type(s)
- concept_is_in_subset
- has_target
