Preferred Label : Nezutatug;
NCIt definition : A humanized immunoglobulin G1 (IgG1) monoclonal antibody directed against the human
epidermal growth factor receptor 3 (HER3; ERBB3), with potential antineoplastic activity.
Upon administration, nezutatug targets and binds to HER3 and inhibits its activation.
This may prevent HER3-mediated signaling and inhibit HER3-dependent tumor cell proliferation
and differentiation. HER3, a member of the epidermal growth factor receptor (EGFR)
family of receptor tyrosine kinases, is frequently overexpressed in tumors and is
associated with poor prognosis and drug resistance; it has no active kinase domain
but is activated through heterodimerization with other members of the EGFR receptor
family, such as HER2.;
UNII : HZZ2SGC2TW;
CAS number : 2673271-78-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2673271-78-6
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : HMBD-001; HMBD 001;
NCI Metathesaurus CUI : CL1906435;
Origin ID : C199011;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
