Preferred Label : Anti-PD-1 Monoclonal Antibody QL1604;
NCIt synonyms : Anti-PD1 Monoclonal Antibody QL1604;
NCIt definition : A humanized monoclonal antibody directed against the negative immunoregulatory human
cell receptor programmed cell death protein 1 (PD-1; PDCD1; CD279), with potential
immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-PD-1
monoclonal antibody QL1604 targets, binds to and inhibits PD-1 and its downstream
signaling pathways. This may restore immune function through the activation of T-cells
and T-cell-mediated immune responses against tumor cells. PD-1, a transmembrane protein
in the immunoglobulin superfamily (IgSF) expressed on T-cells, functions as an immune
checkpoint that negatively regulates T-cell activation and effector function when
activated by its ligands programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation
274; CD274) or 2 (PD-L2); it plays an important role in tumor evasion from host immunity.;
Molecule name : QL-1604; QL 1604;
NCI Metathesaurus CUI : CL1906425;
Origin ID : C198993;
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target