MPS1 Kinase Inhibitor NMS-01940153E

Preferred Label : MPS1 Kinase Inhibitor NMS-01940153E;

NCIt synonyms : MPS1 Inhibitor NMS-01940153E; Monopolar Spindle 1 Inhibitor NMS-01940153E; TTK Inhibitor NMS-01940153E;

NCIt definition : A selective inhibitor of the serine/threonine-protein kinase monopolar spindle 1 (Mps1; TTK), with potential antineoplastic activity. Upon administration, MPS1 kinase inhibitor NMS-01940153E targets, binds to and inhibits the activity of Mps1, a core component of the spindle assembly checkpoint (SAC). Inhibition of Mps1 activity compromises the functioning of SAC, increases chromosome missegregation errors and decreases cancer cell viability. This inhibits tumor cell proliferation. Mps1, a dual-specificity protein kinase expressed in proliferating normal tissues and aberrantly overexpressed in certain tumor types, is activated during mitosis and is essential in proper SAC function, chromosomal alignment and segregation during cellular division.;

Molecule name : NMS-01940153E; NMS 01940153E;

NCI Metathesaurus CUI : CL1906413;

Details

Origin ID

C198989;

UMLS CUI

C5854390;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Dual Specificity Protein Kinase TTK [NCIt concept]

Keyword's position in hierarchy(ies) :

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