Preferred Label : MPS1 Kinase Inhibitor NMS-01940153E;
NCIt synonyms : MPS1 Inhibitor NMS-01940153E; Monopolar Spindle 1 Inhibitor NMS-01940153E; TTK Inhibitor NMS-01940153E;
NCIt definition : A selective inhibitor of the serine/threonine-protein kinase monopolar spindle 1 (Mps1;
TTK), with potential antineoplastic activity. Upon administration, MPS1 kinase inhibitor
NMS-01940153E targets, binds to and inhibits the activity of Mps1, a core component
of the spindle assembly checkpoint (SAC). Inhibition of Mps1 activity compromises
the functioning of SAC, increases chromosome missegregation errors and decreases cancer
cell viability. This inhibits tumor cell proliferation. Mps1, a dual-specificity protein
kinase expressed in proliferating normal tissues and aberrantly overexpressed in certain
tumor types, is activated during mitosis and is essential in proper SAC function,
chromosomal alignment and segregation during cellular division.;
Molecule name : NMS-01940153E; NMS 01940153E;
NCI Metathesaurus CUI : CL1906413;
Origin ID : C198989;
concept_is_in_subset
- has_target
