Preferred Label : Copper Cu 67 SAR-bombesin;
NCIt synonyms : Copper Cu 67 SAR-BBN; 67Cu-SAR-bombesin; 67Cu-SAR-BBN;
NCIt definition : A radioconjugate composed of bombesin (BBN), a tetra-decapeptide that binds with high
affinity to the gastrin-releasing peptide receptor (GRPR), linked by the sarcophagine
chelator (SAR) and radiolabeled with the beta-emitting radioisotope copper Cu 67,
with potential antineoplastic activity. Upon administration of copper Cu 67 SAR-BBN,
the BBN moiety targets and binds to GRPR, thereby delivering a cytotoxic dose of beta
radiation to GRPR-expressing tumor cells. GRPR, also called bombesin receptor 2 (BB2),
is a seven-transmembrane G protein-coupled receptor belonging to the bombesin receptor
family. It is overexpressed in certain types of cancers.;
NCI Metathesaurus CUI : CL1906404;
Origin ID : C198982;
concept_is_in_subset
- has_target
