Preferred Label : Gcn5p;
NCIt definition : Gcn5p is a transcriptional coactivator required for correct expression of various
genes in yeast. Several transcriptional regulators, including Gcn5p, possess intrinsic
histone acetyltransferase (HAT) activity in vitro.;
NCIt note : Containing a bromodomain, Gcn5p is a general transcriptional activator operating in
concert with other DNA-binding transcriptional activators, such as GCN4 or HAP2/3/4.
Gcn5p functions in the SAGA adaptor/HAT complex as a nucleosomal histone acetyltransferase
to promote transcriptional activation. HAT Gcn5p also functions as a heterodimer with
ada2 as part of the ADA adaptor/HAT complex that consists of hfi1/ada1, ada2, ada3,
spt20/ada5 and gcn5. It has a strong preference for Lysine 14 of H3 and a lower preference
for Lysines 8, 16 of H4. (from SWISS-PROT Q03330, SGD S0003484, LocusLink 2648);
Origin ID : C19894;
UMLS CUI : C1171569;
Semantic type(s)
- UMLS correspondences (same concept)
- gene_product_has_organism_source
- gene_product_is_physical_part_of
