KMT2A/TET1 Fusion Gene

Preferred Label : KMT2A/TET1 Fusion Gene;

NCIt synonyms : MLL-LCX Fusion Gene; MLL-TET1 Fusion Gene; KMT2A::TET1 Fusion Gene; TET1::KMT2A Fusion Gene; KMT2A-TET1 Fusion Gene;

NCIt definition : A fusion gene that results from a chromosomal translocation, t(10;11)(q21.3;q23.3), which fuses exon 7, exon 8 or exon 9 of the KMT2A gene with exon 9, exon 10 or exon 12 of the TET1 gene. This chromosomal rearrangement is associated with acute myeloid leukemia with a variant KMT2A rearrangement.;

NCI Metathesaurus CUI : CL1906316;

Details

Origin ID

C198871;

gene_encodes_gene_product
- KMT2A/TET1 Fusion Protein [NCIt concept]
gene_has_abnormality
- t(10;11)(q21.3;q23.3) [NCIt concept]
gene_involved_in_molecular_abnormality
- TET1-KMT2A Fusion Protein Expression [NCIt concept]
- t(10;11)(q21.3;q23.3) [NCIt concept]
gene_involved_in_pathogenesis_of_disease
- Acute Myeloid Leukemia with t(10;11)(q21.3;q23.3); TET1-KMT2A [NCIt concept]
gene_mapped_to_disease
- Acute Myeloid Leukemia with t(10;11)(q21.3;q23.3); TET1-KMT2A [NCIt concept]
related_to_genetic_biomarker
- KMT2A Gene [NCIt concept]
- TET1 Gene [NCIt concept]

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