Modified Interleukin-2 LTC004

Preferred Label : Modified Interleukin-2 LTC004;

NCIt synonyms : Modified IL-2 LTC004;

NCIt definition : A modified form of the recombinant form of human endogenous cytokine interleukin-2 (IL-2), with potential immunoregulatory and antineoplastic activities. Upon injection of modified IL-2 LTC004, IL-2 binds to the IL-2 receptor beta (CD122) and gamma (CD132) subunits (IL2Rb/g) that are expressed on CD8 T effector cells and natural killer (NK) cells, thereby activating IL2R-mediated signaling within these immune cells. The activation of T- and NK cells mediates cytolytic immune responses against tumor cells causing tumor cell destruction and inhibition of tumor cell proliferation. The additional disulfide bonds in LTC004 reduces binding of IL-2 to IL-2 receptor alpha (IL2Ralpha; IL-2Ra) and thereby reduces IL-2Ra-mediated toxicities.;

Molecule name : LTC 004; LTC-004;

NCI Metathesaurus CUI : CL1905861;

Details

Origin ID

C198702;

chemical_or_drug_affects_gene_product
- Interleukin-2 Receptor [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Cytokine Receptor Activation [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Gene Regulation Process [NCIt concept]
- Immunopotentiation [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
- Intercellular Communication Induction [NCIt concept]
- Lymphocyte Activation Process [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

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