Posterior Sex Combs

Preferred Label : Posterior Sex Combs;

NCIt synonyms : Posterior Sex Combs Protein;

NCIt definition : The Drosophila gene Posterior Sex Combs (Psc) encodes a ring-type zinc finger DNA binding protein (Polycomb group) involved in negative regulation of expression patterns of the antennapedia and bithorax homeotic selector gene complexes, and hence maintenance of segmental determination. Similar sequences have been identified in Homo sapiens and Mus musculus. Psc interacts genetically with z, brm, Sce, mxc, Asx, and several other genes. Mutations in Psc generate malformations of the longitudinal tracts. (from SWISS-PROT P35820, FlyBase 0005624, and NCI);

Details

Origin ID

C19869;

UMLS CUI

C1256964;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- psc protein, drosophila [MeSH concept]
- psc protein, drosophila [MeSH Supplementary Concept]
gene_product_has_organism_source
- Drosophila [NCIt concept]
gene_product_is_physical_part_of
- Drosophila Polycomb Repressive Complex 1 [NCIt concept]
gene_product_plays_role_in_biological_process
- Pattern Formation [NCIt concept]

Keyword's position in hierarchy(ies) :

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