Preferred Label : Polyhomeotic;
NCIt definition : The Drosophila 'Polycomb' group (PcG) proteins form a large multimeric, chromatin-associated
complex, repress gene expression, and are part of a system responsible for stable
inheritance of gene activity. Polyhomeotic may interact with proteins bound to promoter
complexes and negatively regulate homeotic and segmentation genes, and regulate the
expression of other pair-rule genes such as EVE, FTZ, and H. The Drosophila PcG protein,
polyhomeotic (Ph), contains a SAM domain and shares several motifs with mouse Rae28
protein. Rae28, Mel18, M33, and Bmi1 are components of a mouse multimeric protein
complex. Human HPH1, HPH2, and BMI1 also appear to be part of a multimeric protein
complex. HPH2 interacts with BMI1. Rae28/Mph1, HPH1, HPH2, and Ph share homology in
the zinc finger domain and in homology domains I and II. Homology domains I and II
may mediate the heterodimerization interactions of HPH1 and HPH2. (from OMIM, SWISS-PROT
and NCI);
Origin ID : C19868;
UMLS CUI : C0137798;
Semantic type(s)
- UMLS correspondences (same concept)
- gene_product_has_associated_anatomy
- gene_product_has_organism_source
- gene_product_is_physical_part_of
- gene_product_plays_role_in_biological_process
