Polycomb - CISMeF

Preferred Label : Polycomb;

NCIt definition : The Drosophila gene Polycomb (Pc) encodes a transcriptional repressor required for the segment-specific repression of homeotic selector genes by promoting locus-specific chromatin compaction. Pc may be involved in the stable transmission of a determined state by its effects on chromatin structure. It contains one chromo domain and interacts genetically with ph-p, Antp, E(Pc), Pcl, Asx, and many other genes. Similar sequences have been identified in African clawed frog, Caenorhabditis elegans, Homo sapiens, and Mus musculus. (from SWISS-PROT P26017, FlyBase 0003042, and NCI);

Details

Origin ID

C19867;

UMLS CUI

C0083956;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_product_has_organism_source
- Drosophila [NCIt concept]
gene_product_is_physical_part_of
- Drosophila Polycomb Repressive Complex 1 [NCIt concept]
gene_product_plays_role_in_biological_process
- Transcriptional Repression [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients