Preferred Label : BRAHMA;
NCIt synonyms : BRM;
NCIt definition : The Drosophila gene brahma (brm) encodes a non-specific RNA polymerase II transcription
co-activator, assisting one or more transcriptional activators of ANT-C and BX-C homeotic
genes. Brm can counteract the repressive effect of polycomb protein and exhibits DNA-dependent
ATPase activity. It contains a SNF2 related domain, a DEAD/DEAH box helicase, a helicase
C-terminal domain, and belongs to the SNF2/RAD54 helicase family. Two isoforms (long
and short) may be produced by alternative splicing. Highest expression is seen in
unfertilized eggs and early embryos. It interacts genetically with Antp, trx, Psc,
Pc, hh, and several other genes. Similar sequences have been identified in Caenorhabditis
elegans, Gallus gallus, Homo sapiens, Mus musculus, and Saccharomyces cerevisiae.
(from SWISS-PROT P25439, FlyBase 0000212, and NCI);
Origin ID : C19865;
UMLS CUI : C1337113;
Semantic type(s)
- gene_product_has_biochemical_function
- gene_product_has_organism_source
- gene_product_is_physical_part_of
