" /> Swh3p - CISMeF





Preferred Label : Swh3p;

NCIt synonyms : Rsc8/Swh3; Rsc8; Swh3; YFR037C;

NCIt definition : A subunit of unknown function in the fifteen-protein RSC nucleosome/chromatin remodeling complex, Rsc8/Swh3 is a homolog of the SWI/SNF protein SWI3. Swi3/BAF155 contains a leucine zipper motif typical of many transcription factors. Swh3p undergoes dimerization via the coiled-coil C-terminus, forms a complex with RSC6p, interacts with the SWI2/SNF2 ATPase Sth1p, and appears to mediate multiple RSC interactions. SWI/SNF and RSC share conserved components. SWI/SNF proteins display helicase and ATPase activities and appear to regulate gene transcription by altering local chromatin structure. RSC complex is required for transcriptional regulation and nucleosome positioning. RSC maintains a repressive chromatin structure at certain inducible promoters. (from SGD; NAR 26:3739, 1998; EMBO J. 18:2836, 1999; and NCI);

NCIt note : Homologous_Protein: BAF155; Protein_Interacts_With: Rsc6, Sth1; SGDID S0001933; Protein_Family: SWI Family;

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Keyword's position in hierarchy(ies) : arborescence

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18/05/2024


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