Preferred Label : BTK Inhibitor TQB3702;
NCIt synonyms : Bruton's Tyrosine Kinase Inhibitor TQB3702;
NCIt definition : An orally bioavailable inhibitor of Bruton's tyrosine kinase (BTK; Bruton agammaglobulinemia
tyrosine kinase), with potential antineoplastic activity. Upon oral administration,
BTK inhibitor TQB3702 targets, binds to and inhibits the activity of BTK. This prevents
both the activation of the B-cell antigen receptor (BCR) signaling pathway and BTK-mediated
activation of downstream survival pathways. This leads to an inhibition of the growth
of malignant B-cells that overexpress BTK. BTK, a member of the Src-related BTK/Tec
family of cytoplasmic tyrosine kinases, is overexpressed or mutated in B-cell malignancies;
it plays an important role in the development, activation, signaling, proliferation
and survival of B-lymphocytes.;
Molecule name : TQB-3702; TQB 3702;
NCI Metathesaurus CUI : CL1913984;
Origin ID : C198220;
UMLS CUI : C5786912;
Semantic type(s)
- concept_is_in_subset
- has_target
