Topoisomerase-II Inhibitor

Preferred Label : Topoisomerase-II Inhibitor;

NCIt synonyms : Topoisomerase-II Inhibitors;

NCIt definition : Any substance that inhibits topoisomerase-II, a topoisomerase that relieves torsional stress in a DNA molecule by cutting both strands of the DNA double helix. A topoisomerase II inhibitor can either stabilize the DNA-protein complex or inhibit the catalytic activity of the enzyme. Inhibition of topoisomerase-II causes DNA damage, inhibition of DNA replication, and apoptosis.;

ChEBI ID : CHEBI:50750;

Details

Origin ID

C1968;

UMLS CUI

C1519554;

Automatic exact mappings (from CISMeF team)
- Product containing topoisomerase inhibitor (product) [SNOMED CT concept]
- topoisomerase I inhibitors [MeSH concept]
- topoisomerase I inhibitors [MeSH Descriptor]
Currated CISMeF NLP mapping
- topoisomerase II inhibitors [MeSH Descriptor]
- topoisomerase II inhibitors [MeSH concept]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- topoisomerase II inhibitors [MeSH concept]
- topoisomerase II inhibitors [MeSH Descriptor]

Keyword's position in hierarchy(ies) :

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