Preferred Label : Mercaptopurine;
NCIt synonyms : Mern; 6-Purinethiol; 6-MP; Mercapto-6-purine; Mercapurin; 1,7-Dihydro-6H-purine-6-thione; 7-Mercapto-1,3,4,6-tetrazaindene; 1,7-Dihydro-6H-purine-6-thione Monohydrate; 6-Mercaptopurine Monohydrate; 6-Thiopurine; Purine-6-thiol Monohydrate; 6 Thiohypoxanthine; Leupurin; 6-Thioxopurine; 6 Thiopurine; Azathiopurine; Purine-6-thiol (8CI); 6H-Purine-6-thione, 1,7-dihydro- (9CI);
NCIt related terms : Purimethol; Ismipur; 6 MP; Puri-Nethol; Purine-6-thiol, monohydrate; Bw 57-323H; NCI-C04886; Purinethol; 6-Mercaptopurine; Purine, 6-mercapto-; 3H-Purine-6-thiol; Leukerin; Mercaleukin; Mercaleukim; U-4748;
NCIt definition : A thiopurine-derivative antimetabolite with antineoplastic and immunosuppressive activities.
Produced through the metabolism of mercaptopurine by hypoxanthine-guanine phosphoribosyltransferase
(HGPRT), mercaptopurine metabolites 6-thioguanosine-5'-phosphate (6-thioGMP) and 6-thioinosine
monophosphate (T-IMP) inhibit nucleotide interconversions and de novo purine synthesis,
thereby blocking the formation of purine nucleotides and inhibiting DNA synthesis.
This agent is also incorporated into DNA in the form of deoxythioguanosine, which
results in the disruption of DNA replication. In addition, mercaptopurine is converted
to 6-methylmercaptopurine ribonucleoside (MMPR) by 6-thiopurine methyltransferase;
MMPRs are also potent inhibitors of de novo purine synthesis. (NCI04);
Alternative definition : NCI-GLOSS: A drug used to treat acute lymphatic leukemia. It belongs to the family
of drugs called antimetabolites.;
UNII : E7WED276I5;
InChIKey : WFFQYWAAEWLHJC-UHFFFAOYSA-N;
CAS number : 6112-76-1;
Drug name : Ismipur; Mercaptina; Mercaleukim; Alti-Mercaptopurine; Mercaptopurinum; Puri-Nethol; Purinethiol; Flocofil; Leukerin;
Molecule name : U-4748; BW 57-323H; WR-2785;
Chemical formula : C5H4N4S.H2O;
NSC code : 755;
ChEBI ID : CHEBI:31822;
Codes from synonyms : NSC0000755; CDR0000046639; 06674; CDR0000413955; NSC0038887; 327;
Origin ID : C195;
UMLS CUI : C0000618;
Automatic exact mappings (from CISMeF team)
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
