Histone Deacetylase Inhibitor

Preferred Label : Histone Deacetylase Inhibitor;

NCIt synonyms : HDAC Agent;

NCIt related terms : HDAC inhibitor;

NCIt definition : Any substance that inhibits histone deacetylase, an enzyme that catalyzes the removal of acetyl groups from core histones. Inhibition of histone deacetylase can result in hyperacetylation of histones, with an effect on gene expression and cell differentiation.;

Alternative definition : NCI-GLOSS: A substance that causes a chemical change that stops tumor cells from dividing. HDAC inhibitors are being studied in the treatment of cancer.;

ChEBI ID : CHEBI:61115;

Codes from synonyms : CDR0000473970; CDR0000472896;

Details

Origin ID

C1946;

UMLS CUI

C1512474;

Currated CISMeF NLP mapping
- Substance with histone deacetylase inhibitor mechanism of action (substance) [SNOMED CT concept]
- histone deacetylase inhibitors [MeSH Descriptor]
- histone deacetylase inhibitors [MeSH concept]
See also inter- (CISMeF)
- Histone deacetylase inhibitor (disposition) [SNOMED CT concept]
- Product containing histone deacetylase inhibitor (product) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing histone deacetylase inhibitor (product) [SNOMED CT concept]
- Substance with histone deacetylase inhibitor mechanism of action (substance) [SNOMED CT concept]
- histone deacetylase inhibitors [MeSH concept]
- histone deacetylase inhibitors [MeSH Descriptor]

Keyword's position in hierarchy(ies) :

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