NCIt definition : An Fc-enhanced immunoglobulin G1 (IgG1) monoclonal antibody directed against the costimulatory
receptor CD137 (4-1BB; tumor necrosis factor receptor superfamily member 9; TNFRSF9)
covalently linked to a peptide mask, with potential immunostimulating and antineoplastic
activities. Upon administration, anti-CD137 agonistic monoclonal antibody ADG206 is
selectively activated in the tumor microenvironment (TME), and targets, binds to,
and activates CD137 expressed on a variety of leukocyte subsets including activated
T-lymphocytes and natural killer (NK) cells. This enhances CD137-mediated signaling,
induces cytokine production and promotes T-cell mediated anti-tumor immune responses.
CD137, a surface glycoprotein of the tumor necrosis factor receptor superfamily, is
an inducible costimulatory receptor that plays a key role in T-cell proliferation,
survival and cytolytic activity.;