Preferred Label : Anti-TROP2 Antibody-drug Conjugate BAT8008;
NCIt synonyms : Anti-TROP2/Exatecan ADC BAT8008; Anti-TROP2 ADC BAT8008;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody targeting the tumor-associated
antigen (TAA) trophoblast cell surface protein 2 (trophoblast antigen 2; calcium signal
transducer 2; TROP2; TROP-2; TACSTD2; GA733-1; M1S1) conjugated via a cleavable linker
to the camptothecin analog exatecan, with potential antineoplastic activity. Upon
administration of the anti-TROP2 ADC BAT8008, the anti-TROP2 antibody targets and
binds to TROP2 expressed on tumor cells. Upon binding, internalization and linker
cleavage, exatecan is released. Exatecan inhibits DNA topoisomerase I activity, thereby
inhibiting DNA replication and resulting in cell cycle arrest and tumor cell apoptosis.
This inhibits the proliferation of TROP2-expressing tumor cells. TROP2 is a transmembrane
protein overexpressed in various tumors. Its expression is associated with enhanced
tumor aggressiveness, metastasis, drug resistance and increased tumor cell survival.;
Molecule name : BAT 8008; BAT-8008;
NCI Metathesaurus CUI : CL1913093;
Origin ID : C193471;
UMLS CUI : C5785780;
Semantic type(s)
- concept_is_in_subset
- has_target
