Preferred Label : Veludacigib;
NCIt synonyms : DGKzeta Inhibitor BAY2965501; DGKZ Inhibitor BAY2965501; DGKzi BAY2965501; Diacylglycerol Kinase Zeta Inhibitor BAY2965501;
NCIt definition : An orally bioavailable inhibitor of diacylglycerol kinase zeta (DGKzeta), with potential
antineoplastic activity. Upon oral administration, veludacigib inhibits the activity
of DGKzeta. This prevents the phosphorylation of diacylglycerol (DAG) to phosphatidic
acid (PA), and modulates the DAGzeta-regulated cellular signaling pathways. This may
inhibit the proliferation of tumor cells in which DGKzeta is overactivated. DGKzeta
is overexpressed in certain cancer cells and plays an important role in tumor cell
survival. DAGzeta may also play a key role in tumor immunosuppression.;
UNII : A57K8BQ2EV;
CAS number : 2732902-08-6;
Molecule name : BAY-2965501; BAY 2965501;
NCI Metathesaurus CUI : CL1913096;
Origin ID : C193470;
UMLS CUI : C5785779;
Semantic type(s)
- concept_is_in_subset
- has_target
