Preferred Label : Diacylglycerol Kinase Zeta Inhibitor BAY2965501;
NCIt synonyms : DGKzeta Inhibitor BAY2965501; DGKZ Inhibitor BAY2965501; DGKzi BAY2965501;
NCIt definition : An orally bioavailable inhibitor of diacylglycerol kinase zeta (DGKzeta), with potential
antineoplastic activity. Upon oral administration, DGKzeta inhibitor BAY2965501 inhibits
the activity of DGKzeta. This prevents the phosphorylation of diacylglycerol (DAG)
to phosphatidic acid (PA), and modulates the DAGzeta-regulated cellular signaling
pathways. This may inhibit the proliferation of tumor cells in which DGKzeta is overactivated.
DGKzeta is overexpressed in certain cancer cells and plays an important role in tumor
cell survival. DAGzeta may also play a key role in tumor immunosuppression.;
Molecule name : BAY-2965501; BAY 2965501;
NCI Metathesaurus CUI : CL1913096;
Origin ID : C193470;
UMLS CUI : C5785779;
Semantic type(s)
- concept_is_in_subset
- has_target
