Preferred Label : Anti-TROP-2/Antibody-drug Conjugate SHR-A1921;
NCIt synonyms : ADC SHR-A1921; Anti-TROP-2 ADC SHR-A1921; Anti-TROP-2/SHR9265 ADC SHR-A1921;
NCIt definition : An antibody-drug conjugate (ADC) composed of an immunoglobulin G1 (IgG1) monoclonal
antibody directed against the tumor-associated antigen (TAA) trophoblast cell surface
protein 2 (trophoblast antigen 2; calcium signal transducer 2; TROP2; TROP-2; TACSTD2;
GA733-1; M1S1) conjugated, via a cleavable linker, to the exatecan derivative and
topoisomerase-1 inhibitor SHR9265, with potential antineoplastic activity. Upon intravenous
administration, the monoclonal antibody moiety of anti-TROP-2 ADC SHR-A1921 targets
and binds to TROP-2 expressed on tumor cells. Upon binding, internalization and linker
cleavage, SHR9265 is released and inhibits DNA topoisomerase I activity, thereby inhibiting
DNA replication and resulting in cell cycle arrest and apoptosis in tumor cells expressing
TROP-2. TROP-2 is a transmembrane protein overexpressed in various tumors. Its expression
is associated with enhanced tumor aggressiveness, metastasis, drug resistance and
increased tumor cell survival.;
Molecule name : SHR-A1921; SHR A1921;
NCI Metathesaurus CUI : CL1913111;
Origin ID : C193454;
UMLS CUI : C5785765;
Semantic type(s)
- concept_is_in_subset
- has_target
