Preferred Label : JNK1 Inhibitor BMS-986360;
NCIt synonyms : Mitogen-Activated Protein Kinase 8 Inhibitor BMS-986360; c-Jun N-terminal Kinase Inhibitor BMS-986360; JNK1 Inhibitor CC-90001;
NCIt related terms : CC-90001;
NCIt definition : An orally bioavailable, second-generation inhibitor of c-Jun N-terminal kinase 1 (JNK-1;
JNK1; mitogen-activated protein kinase 8; MAPK8), with potential antineoplastic, anti-inflammatory
and anti-fibrotic activities. Upon oral administration, JNK1 inhibitor BMS-986360
selectively targets, binds to and inhibits the activity of JNK1. Inhibition of JNK1-mediated
mitogen-activated protein kinase (MAPK)-signaling pathways induces cell cycle arrest
and apoptosis, decreases migration and invasion, and inhibits proliferation in JNK1-overexpressing
cancer cells. Inhibition of JNK1-mediated pathways may also decrease fibrosis. JNK1,
a member of the MAPK family and stress-activated protein, plays a role in the MAPK-mediated
signaling pathway. It is often dysregulated in cancer cells and fibrosis.;
UNII : JD5ZWE631K;
CAS number : 1403859-14-2;
Molecule name : BMS 986360; BMS-986360; CC-90001; CC 90001;
NCI Metathesaurus CUI : CL1912827;
Origin ID : C192826;
UMLS CUI : C5785447;
Semantic type(s)
- concept_is_in_subset
- has_target
