Preferred Label : Anti-CD8b Antibody/IL-2 Mutein Fusion Protein AB248;
NCIt synonyms : CD8-targeted IL-2 Mutein Immunotherapeutic AB248; Anti-CD8 Beta Chain Antibody/Interleukin-2 Mutein Fusion Protein AB248;
NCIt definition : A recombinant fusion protein comprised of a humanized immunoglobulin G1 (IgG1) antibody
targeting the T-cell surface glycoprotein CD8 beta chain (CD8b) linked to an affinity-attenuated
interleukin-2 (IL-2) mutein, with potential immunostimulating and antineoplastic activities.
Upon administration of anti-CD8b antibody/IL-2 mutein fusion protein AB248, the antibody
moiety specifically targets and binds to CD8 T-cells, thereby allowing for the IL-2
mutein moiety to specifically bind to IL-2R and activate IL-2R-mediated signaling
in CD8 T-cells. This enhances cytotoxic T-lymphocytes (CTLs)-mediated cytotoxic immune
responses against tumor cells. The IL-2 mutein has a reduced affinity to IL-2 receptor
subunit alpha (IL-2Ralpha; CD25) and beta (IL-2Rbeta; CD122), which promotes the selective
activation of CD8 T-cells over natural killer (NK) cells and immunosuppressive regulatory
T-cells (Tregs). The IL-2Ralpha/IL-2R beta-mediated activation of NK cells and immunosuppressive
Tregs is associated with immunosuppression and adverse effects including vascular
leak syndrome (VLS).;
Molecule name : AB 248; AB-248;
NCI Metathesaurus CUI : CL1912879;
Origin ID : C192789;
UMLS CUI : C5785412;
Semantic type(s)
- concept_is_in_subset
- has_target
