Preferred Label : Etakafusp Alfa;
NCIt synonyms : CD8-targeted IL-2 Mutein Immunotherapeutic AB248; Anti-CD8 Beta Chain Antibody/Interleukin-2 Mutein Fusion Protein AB248; Anti-CD8b Antibody/IL-2 Mutein Fusion Protein AB248;
NCIt definition : A recombinant fusion protein comprised of a humanized immunoglobulin G1 (IgG1) antibody
targeting the T-cell surface glycoprotein CD8 beta chain (CD8b) linked to an affinity-attenuated
interleukin-2 (IL-2) mutein, with potential immunostimulating and antineoplastic activities.
Upon administration of etakafusp alfa, the antibody moiety specifically targets and
binds to CD8 T-cells, thereby allowing for the IL-2 mutein moiety to specifically
bind to IL-2R and activate IL-2R-mediated signaling in CD8 T-cells. This enhances
cytotoxic T-lymphocytes (CTLs)-mediated cytotoxic immune responses against tumor cells.
The IL-2 mutein has a reduced affinity to IL-2 receptor subunit alpha (IL-2Ralpha;
CD25) and beta (IL-2Rbeta; CD122), which promotes the selective activation of CD8
T-cells over natural killer (NK) cells and immunosuppressive regulatory T-cells (Tregs).
The IL-2Ralpha/IL-2R beta-mediated activation of NK cells and immunosuppressive Tregs
is associated with immunosuppression and adverse effects including vascular leak syndrome
(VLS).;
UNII : 5Y27P3LNU6;
CAS number : 2852680-28-3;
Molecule name : AB 248; AB-248;
NCI Metathesaurus CUI : CL1912879;
Origin ID : C192789;
UMLS CUI : C5785412;
Semantic type(s)
- concept_is_in_subset
- has_target
