Preferred Label : Anti-CD7 CAR T Cells BT-007;
NCIt synonyms : CD7 CAR-T Cells BT-007;
NCIt definition : A preparation of T-lymphocytes that have been genetically engineered and transduced
with a lentiviral vector to express a chimeric antigen receptor (CAR) directed against
the tumor-associated antigen (TAA) CD7, the co-immunostimulatory signaling domain
4-1BB (CD137) and the intracellular CD3 zeta domain (CD3z), with potential immunostimulating
and antineoplastic activities. Upon administration, the anti-CD7 CAR T cells BT-007
specifically recognize and bind to CD7-expressing tumor cells, resulting in specific
T-cell-mediated tumor cell lysis. CD7 is a transmembrane glycoprotein expressed by
T-cells and natural killer (NK) cells and their precursors. It is expressed in the
majority of lymphoblastic T-cell leukemias and lymphomas and in a subset of peripheral
T-cell lymphomas.;
Molecule name : BT-007; BT 007;
NCI Metathesaurus CUI : CL1912935;
Origin ID : C192687;
UMLS CUI : C5785375;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
