NCIt definition : A recombinant immunoglobulin G1 (IgG1) monoclonal antibody targeting the co-inhibitory
molecule and immune checkpoint inhibitor T-cell immunoreceptor with immunoglobulin
(Ig) and immunoreceptor tyrosine-based inhibitory motif (ITIM) domains (TIGIT), with
potential immune checkpoint inhibitory activity. Upon administration, anti-TIGIT monoclonal
antibody PM1021 targets and binds to TIGIT expressed on various immune cells, particularly
on tumor-infiltrating lymphocytes (TILs), thereby preventing the interaction of TIGIT
with its ligands CD112 (nectin-2; poliovirus receptor related-2; PRR2; PVRL2) and
CD155 (poliovirus receptor; PVR; nectin-like protein 5; NECL-5). This enhances the
interaction of CD112 and CD155 with the costimulatory receptor CD226 (DNAX Accessory
molecule-1; DNAM-1), which is expressed on immune cells, such as natural killer (NK)
cells and CD8 T-cells. This leads to CD226 dimerization and CD226-mediated signaling
and activates the immune system to exert a T-cell-mediated immune response against
cancer cells. TIGIT, a member of the Ig super family (IgSF) and an immune inhibitory
receptor, plays a key role in the suppression of T-cell proliferation and activation;
it is involved in tumor cell immune evasion, and the inhibition of antiviral immune
responses.;
Semantic type(s)