Preferred Label : CXCR4 Inhibitor GPC-100;
NCIt definition : An inhibitor of C-X-C chemokine receptor type 4 (CXCR4), with potential hematopoietic
stem cell (HSC)-mobilizing activity. Upon administration, CXCR4 inhibitor GPC-100
targets and binds to CXCR4, thereby preventing the binding of stromal-cell derived
factor-1 (SDF-1; C-X-C motif chemokine ligand 12; CXCL12) to CXCR4. This results in
HSC release from the bone marrow and HSC movement into the peripheral circulation.
The CXCL12/CXCR4 signaling pathway plays an important role in the migration and retention
of HSC in the bone marrow.;
Molecule name : GPC 100; GPC-100;
NCI Metathesaurus CUI : CL1912591;
Origin ID : C192651;
UMLS CUI : C5785354;
Semantic type(s)
- concept_is_in_subset
- has_target
