Preferred Label : Lead Pb 212 Pentixather;
NCIt synonyms : Lead 212-labeled Pentixather; 212-Lead Pentixather; 212Pb-Pentixather; Lead Pb 212-Pentixather;
NCIt definition : A radioconjugate composed of pentixather, a chemokine receptor C-X-C chemokine receptor
type 4 (CXCR4)-targeting ligand, conjugated to the alpha-emitting radioisotope lead
Pb 212, with potential antineoplastic activity. Upon administration, lead Pb 212 pentixather
targets and binds to CXCR4-expressing cancer cells. This allows for the specific delivery
of a cytotoxic dose of alpha radiation to CXCR4-expressing cancer cells. CXCR4, a
marker of poorly differentiated cells, is overexpressed on various cancer cells, and
plays a key role in tumor growth, progression, invasiveness and metastasis.;
NCI Metathesaurus CUI : CL1912588;
Origin ID : C192646;
UMLS CUI : C5785349;
Semantic type(s)
- concept_is_in_subset
- has_target
