Preferred Label : NLRP3 Inhibitor DFV890;
NCIt synonyms : NLRP3 Antagonist DFV890;
NCIt definition : An orally bioavailable inhibitor of the innate immune signaling sensor nucleotide-binding
domain and leucine-rich repeat (NLR) family pyrin domain containing 3 (NLRP3; NACHT,
LRR and PYD containing protein 3; NALP3), with potential immunomodulatory, anti-inflammatory
and antineoplastic activities. Upon oral administration, NLRP3 inhibitor DFV890 specifically
binds to and inhibits NLRP3, the sensor component of the NLRP3 inflammasome, and prevents
the formation of the NLRP3 inflammasome. This inhibits the production of the pro-inflammatory
cytokines interleukin-1-beta (IL-1beta) and interleukin-18 (IL-18), which may prevent
or reduce inflammation. NLRP3 plays an important role in immunity and inflammation.
Inflammasome activation may also be involved in disease initiation and progression
in myeloid malignancies.;
Molecule name : IFM 2427; IFM-2427; DFV-890; DFV 890;
NCI Metathesaurus CUI : CL1912589;
Origin ID : C192645;
UMLS CUI : C5785348;
Semantic type(s)
- concept_is_in_subset
- has_target
