NCIt definition : An immunoglobulin G1 (IgG1) monoclonal antibody directed against the human tumor-associated
antigen (TAA) CD70, with potential immunomodulatory and antineoplastic activities.
Upon administration, anti-CD70 monoclonal antibody IMM40H selectivity targets and
binds to CD70, which blocks CD70-mediated signaling. This may inhibit cellular proliferation
and survival of CD70-expressing tumor cells, and may modulate the immune system to
inhibit inflammatory signals and increase antigen-specific T-cell responses in the
tumor microenvironment (TME). In addition, IMM40H induces antibody-dependent cellular
cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and complement-dependent
cytotoxicity (CDC) against CD70-expressing tumor cells. CD70, a member of the tumor
necrosis factor (TNF) family, is aberrantly expressed on malignant myeloid blasts
while absent from healthy hematopoietic progenitor cells.;
Semantic type(s)