Preferred Label : Anti-CD228/4-1BB Bispecific Agent SGN-BB228;
NCIt synonyms : Anti-CD228/Anti-4-1BB Bispecific Agent SGN-BB228; Bispecific Antibody-Anticalin Fusion Protein SGN-BB228; Anti-CD228/4-1BB Bispecific Antibody-Anticalin Molecule; Mabcalin SGN-BB228; CD228 x 4-1BB Bispecific Agent SGN-BB228;
NCIt definition : A bispecific agent composed of a human immunoglobulin G4 (IgG4) monoclonal antibody
targeting the cell surface antigen cluster of differentiation (CD228; melanotransferrin;
MFI2; MELTF; p97) fused to a binding protein targeting the costimulatory receptor
4-1BB (CD137; tumor necrosis factor receptor superfamily member 9; TNFRSF9), with
potential immunostimulating and antineoplastic activities. Upon administration, anti-CD228/4-1BB
bispecific agent SGN-BB228 simultaneously targets and binds to CD228 expressed on
the surface of tumor cells and 4-1BB expressed on a variety of leukocyte subsets including
activated T-lymphocytes. This crosslinks CD228-expressing tumor cells and 4-1BB-expressing
T-cells, and activates 4-1BB signaling locally in the tumor microenvironment (TME).
This results in cytotoxic T-cell co-stimulation, enhances T-lymphocyte-mediated anti-tumor
activity and leads to cytotoxic T-cell-mediated lysis of CD228-expressing tumor cells.
CD228, a cell-surfaced, glycosylphosphatidylinoitol (GPI)-anchored glycoprotein that
belongs to the transferrin family of iron-binding proteins, is upregulated in certain
tumor types including melanoma, mesothelioma and lung cancer. 4-1BB, a surface glycoprotein
of the tumor necrosis factor receptor superfamily, is an inducible costimulatory receptor
that plays a key role in T-cell proliferation, survival and cytolytic activity.;
Molecule name : SGN BB228; SGN-BB228; PRS-346; PRS 346;
NCI Metathesaurus CUI : CL1905547;
Origin ID : C192209;
UMLS CUI : C5784980;
Semantic type(s)
- concept_is_in_subset
- has_target
