Preferred Label : Anti-interleukin-13 Receptor Alpha 2 CAR T Cells YYB-103;
NCIt synonyms : IL13Ra2-targeted CAR-T Cells YYB-103; Anti-IL13Ra2 CAR T Cells YYB-103; Anti-IL13Ralpha2 CAR T Cells YYB-103; Anti-IL13Ra2 CAR T-cells YYB-103; Anti-IL13Ra2 CAR-T Cells YYB-103;
NCIt definition : A preparation of T-lymphocytes genetically modified to express a chimeric antigen
receptors (CAR) specific for interleukin-13 receptor alpha 2 (IL13Ra2), with potential
immunostimulating and antineoplastic activities. Upon administration, the anti-IL13Ra2
CAR T cells YYB-103 target and bind to IL13Ra2 expressed on the surface of tumor cells.
This induces selective toxicity in tumor cells expressing IL13Ra2. IL13Ra2, a cancer-associated
receptor, is overexpressed by a variety of tumor cell types including glioblastoma
multiforme (GBM); it is associated with increased invasiveness of tumor cells.;
Molecule name : YYB-103; YYB 103;
NCI Metathesaurus CUI : CL1905576;
Origin ID : C192172;
UMLS CUI : C5784958;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
