" /> Pegylated Orthogonal IL-2 STK-009 - CISMeF





Preferred Label : Pegylated Orthogonal IL-2 STK-009;

NCIt synonyms : Orthogonal IL-2 Ligand STK-009; OrthoIL-2 STK-009; Pegylated IL-2 Mutein STK-009; Orthogonal IL-2 STK-009;

NCIt definition : A polyethylene glycol (PEG)-conjugated mutein form of the cytokine interleukin-2 (IL-2), with potential and specific activity on enhancing proliferation, survival and anti-tumor activity of engineered orthoIL-2Rb-expressing CAR T-cells. Upon subcutaneous administration, pegylated orthogonal (ortho) IL-2 STK-009 specifically targets and binds to mutated orthoIL-2Rbeta (hoRbeta; hoRb) that is specifically expressed on certain engineered CAR T-cells. This induces selective proliferation, survival, and cytotoxic function of orthoIL-2Rbeta-expressing CAR T-cells, which enhances tumor cell killing and decreases tumor cell proliferation. Pegylation of IL-2 protects the cytokine from degradation. STK-009 does not bind to the wild type (WT) IL-2b receptor and does not activate IL-2-mediated signaling in bystander T- and NK-cells, thereby limiting systemic toxicity.;

Molecule name : STK-009; STK 009;

NCI Metathesaurus CUI : CL1905607;

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15/05/2024


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